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KMID : 0616120220530020070
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Korean Journal of Pharmacognosy
2022 Volume.53 No. 2 p.70 ~ p.78
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Skin Regeneration and Whitening Effects of the Complex Extract of Dendrobii Caulis and Centella asiatica
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Kim Dong-Myong
Park Hye-Ryung
Lee Hyung-Kon
Kwon Yong-Seong
Choi Yeon-Mea
Han In-Suk
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Abstract
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The objective of this study was to assess the effect of preventing pigmentation caused by external stimuli, promoting skin regeneration and whitening of the skin composition containing complex extract of Dendrobii Caulis and Centella asiatica (CE). We evaluated cell viability, tyrosinase and melanin inhibition activity, skin irritation test, and skin moisturizing and regenerative effects using CE. As a result of the tyrosinase inhibitory activity, 100 μg/mL CE (35.31%) showed higher value than kojic acid (21.32%). The results of melanin synthesis inhibition in B16F10 melanoma cells after treatment with α-melanocyte stimulating hormone showed a similar level of activity to that of arbutin, indicating an excellent whitening effect. In clinical test of the skin composition containing CE, we confirmed that CE is non-irritated in human skin primary irritation test as well as have a high skin moisturizing and regenerative effect. From these results, we suggested the CE not only prevents skin damage and pigmentation caused by external stimuli but has remarkable skin brightening activity and skin regeneration effect.
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KEYWORD
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Dendrobii Caulis, Centella asiatica, Skin composition, Skin-regeneration, Skin-brightening
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